This leaflet is designed for people taking Gliclazide or Glimepiride for type 2 diabetes.

What does this medication do?

These medications work to increase the release of insulin from the pancreas and therefore lower sugars in the blood.

How do I take this medication?

It is best to take the tablets shortly before eating or with your meal once or twice a day as

If you forget to take a tablet, wait until the next dose is due. Do not take two doses

Who can’t take this medication?

Gliclazide or Glimepiride may not be suitable for certain people. These tablets are not suitable for women who are pregnant or if you have severe liver or kidney problems. They also don’t work in type 1 diabetes or if you have had your pancreas removed.

Your prescriber will review your medical history when prescribing Gliclazide or Glimepiride to check if it is suitable for you.

What are the common side effects?

Many people experience no side effects taking gliclazide or glimepiride. However, like all
medicines, Gliclazide or Glimepiride can cause side effects. Side effects can be less likely
if you take these tablets with a meal.

The main side effect to be aware of is hypoglycaemia or low blood sugars. If you feel shaky, anxious, sweaty, extremely hungry or dizzy it may be a sign that your blood sugars
have dropped too low. You should have a small sugary snack (dextrose tablets, sugary drink) followed by a snack containing carbohydrates such as a sandwich. You may want to test your blood sugar and if it is under 4mmol/L this is an episode of hypoglycaemia.

Some people also experience nausea, indigestion, tummy pain or an itchy rash when taking this medication.

This medication may give you a tendency to put on weight, so it is important that you maintain healthy eating habit

Do I need to be monitored?

You need to test your blood sugars if you drive, are having episodes of hypoglycaemia or
are advised to by your healthcare provider when taking this medication. Your prescriber
will be able to advise you if you need to test your blood sugars and how to do this.

Your doctor will monitor your kidneys and liver function whilst you are on this drug.

Are there any sick day rules?

You can continue to take this medication whilst you are unwell.

If you usually check your blood sugar at home, it is advised you increase the number of
times you check your blood sugar when unwell.

What about driving?

Certain people with diabetes need to inform the Driver and Vehicle Licensing Agency
(DVLA). This depends on your medication regimen, whether you hold a group 1 or group
2 licence and other individualised factors.

Full advice can be found via the DVLA website or

If you have any queries about this medication, contact your diabetes team, GP or pharmacist.